Molecular Formula | C10H9ClN2O4 |
Molar Mass | 256.64 |
Density | 1.438 |
Boling Point | 475.4±38.0 °C(Predicted) |
pKa | -4.29±0.50(Predicted) |
Physical and Chemical Properties | Pure products are light yellow crystals, m.p.85.3 ~ 86.1 ℃, industrial products are light yellow crystals, insoluble in water, soluble in toluene and other organic solvents. |
Use | N-(4-chloro-2-nitrophenyl) acetoacetamide is an intermediate of the herbicide quetiapine. |
production method | the preparation method is to add a solvent in the reactor, under stirring, P-chloro-o-nitroaniline (also known as red base 3GL) and catalyst were added, heated to slight reflux, and then diketene was added dropwise for about 1H. After completion of dropwise addition, the reaction was continued for 2H under reflux, it was cooled to 50 ° C., transferred to a crystallization kettle, and cooled to give a crystal filtration, and the filter cake was dried to be the finished product. |